Open AccessThe relationship between low serum magnesium level and intracerebral hemorrhage hematoma expansion
Author(s) -
Rending Zhu,
Xiaolu He,
Yanqun Du,
Nan Chen,
Wei Wang,
Yanchun Sun,
Jian Sun,
Wanjun Liu,
Xun Wang,
Chuanqin Fang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000018719
Subject(s) - medicine , intracerebral hemorrhage , cochrane library , hypomagnesemia , hematoma , medline , magnesium , meta analysis , intensive care medicine , surgery , subarachnoid hemorrhage , materials science , political science , law , metallurgy
Background: Hematoma expansion (HE) is related to clinical deterioration and unfavorable prognosis in intracerebral hemorrhage (ICH). Some studies have revealed that low serum magnesium level is associated with larger hematoma volume at admission, HE, and unfavorable outcomes. However, the conclusions remain unsettled. The purpose of this study is to evaluate the association between low serum magnesium level and HE by meta-analysis. Methods: We will search the following electronic bibliographic databases: PubMed, Medline, Embase, Web of Science, and The Cochrane Library. Studies will be included if they reported a relationship of low serum magnesium level and HE, mortality or poor outcome. Results: The results of this study will be submitted to a peer-reviewed journal for publication. Conclusion: This will be the first systematic review and meta-analysis to evaluate the association of HE following ICH with Hypomagnesemia. We look forward to the results will offer scientific proof to predict HE for ICH patients with low serum magnesium level. PROSPERO registration number: This protocol has been registered in the PROSPERO network with number: CRD42019135995.