Open AccessRare malignant ulcer related to primary intestinal diffuse large B-cell lymphoma
Author(s) -
Ning Jia,
Yanping Tang,
Yang Li
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000018590
Subject(s) - medicine , primary (astronomy) , lymphoma , dermatology , gastroenterology , diffuse large b cell lymphoma , pathology , physics , astronomy
Rationale: The specific pathogenesis of the diffuse large B-cell lymphoma(DLBCL)is still indefinite and argumentative. It is known that DLBCL is the most common type of non-Hodgkin's lymphomas (NHL). A lot of cases of DLBCL such as primary gastric diffuse large B-cell lymphoma(PG-DLBCL) are reported. However, primary intestinal diffuse large B-cell lymphoma(PI-DLBCL) is unusual. Patient concerns: We present a case of a 57-year-old male diagnosed in the Gastroenterology Department, which presented a bleeding duodenal ulcer with irregular borders. Diagnoses: The immunohistochemical staining showed: CD20(+++), CD10(+) and Ki-67>40%. Interventions: The patient was successfully treated by Poly-chemotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vindesine and prednisolone). Outcomes: After 6 courses of chemotherapy treatment, the duodenal ulcer was completely healed by reviewing the UGIE. Lessons: Our report might give further strength to avoiding the erroneous and missed diagnosis for PI-DLBCL which is different from common duodenal ulcer.