Open AccessThe relationship of MicroRNA-21 and plaque stability in acute coronary syndrome
Author(s) -
Wangwei He,
Liyuan Zhu,
Yhu-Chering Huang,
Zhang Yinfen,
Weimin Shen,
Li-huan Fang,
Jun Li,
Zhuo Wang,
Qiang Xie
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000018049
Subject(s) - medicine , acute coronary syndrome , fibrous cap , myocardial infarction , cardiology , chest pain , vulnerable plaque , coronary artery disease , microrna , coronary atherosclerosis , gene , biochemistry , chemistry
Acute coronary syndrome (ACS) leads to clinical symptoms such as chest pain, dyspnea, and arrhythmia. The occurrence of ACS is mainly related to the vulnerable plaques in the coronary arteries. MicroRNA-21 (miR-21) is widely expressed in cardiovascular disease and considered as a marker of myocardial infarction, but its role in vulnerable atherosclerotic plaque of ACS is poorly studied. The cases of ACS and control group were selected in 2 years. Our results revealed that miR-21 was highly positively correlated with the maximum lipid core area, the number of diseased vessels, the number of macrophages, the number of vulnerable plaques, and negatively correlated with the thickness of fiber caps. In the high expression group, the number of coronary artery lesions, the number of vulnerable plaques, the core area of lipid pools and the number of macrophages were significantly higher than those in the low expression group and the middle expression group. But the high expression group of the thickness of the fiber cap was significantly lower than that of the low expression group and the medium expression group. These studies show that miR-21 is an important factor leading to vulnerable plaque instability in ACS, and it can be a predictor of acute adverse events in coronary heart disease.