Open AccessManagement of an extensive odontogenic keratocyst
Author(s) -
Abdul Ahad Khan,
Saad Al Qahtani,
Ali Azhar Dawasaz,
Shahabe Abullais Saquib,
Shaik Mohammed Asif,
Mohammad Ishfaq,
Mohammad Zahir Kota,
Mohammed Ibrahim
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000017987
Subject(s) - keratocyst , marsupialization , medicine , keratocystic odontogenic tumor , asymptomatic , lesion , surgery , odontogenic , pathology , cyst
The odontogenic keratocyst (OKC), previously known as keratocystic odontogenic tumor has been the most disputable pathologies of the maxillofacial region. Patients with OKC are often asymptomatic but may present with pain, swelling, or discharge. Despite the aggressive nature, previous literature as early as 1970s reported the fact that parakeratinized OKC can be treated by means of marsupialization alone. Patients concerns: The patient had reported with a complaint of pain and swelling in relation with a tooth in mandibular right quadrant. Diagnosis: This case report discusses features of a rare, extensive, panmandibular OKC that is only second of its kind mentioned in the literature. Intervention: As a usual treatment protocol, marsupialization was attempted first. Immunohistochemical analysis revealed reduced expression of Ki-67 and B cell lymphoma 2 (bcl-2) markers after marsupialization from 2 separate sites. However, due to incomplete resolution in the lower right anterior region, an aggressive approach was taken by curetting it out surgically along with associated teeth and cortical plate followed by application of Carnoy's solution. Outcome: Postsurgery uneventful healing of the lesion was noted on regular follow-up visits with complete resolution at 40 months. The case has been followed for 10 years with no sign of relapse and reoccurrence. Conclusions: Based on the expression of markers it can thus be concluded that Ki-67 and bcl-2 are site specific and bear strong relationship with the recurrence of OKCs.