Open AccessAssessment of TNF-α inhibitors in airway involvement of relapsing polychondritis
Author(s) -
Josette Biya,
Sandra Dury,
Jeanne-Marie Perotin,
Claire Launois,
Maxime Dewolf,
Gaëtan Deslée,
F. Lebargy
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000017768
Subject(s) - medicine , relapsing polychondritis , respiratory tract , tumor necrosis factor alpha , respiratory system , respiratory tract infections , disease , intensive care medicine , surgery
Relapsing polychondritis (RP) is a rare immune-mediated disease affecting cartilaginous structures. Respiratory tract manifestations are frequent and constitute a major cause of morbidity and mortality. The present review of the literature was designed to assess the efficacy of tumor necrosis factor alpha (TNF-α) inhibitors in respiratory tract involvement of RP. A MEDLINE literature search was performed from January 2000 to December 2016 to identify all studies and case reports of anti-TNF-α therapy in RP. Articles published in English or French concerning patients with respiratory tract involvement were eligible. Two authors (JB, FL) independently reviewed and extracted data concerning each patient and 2 personal cases were added. Treatment efficacy was assessed according to systemic and/or respiratory criteria. A total of 28 patients (mean age: 41.6 years; 16 females/12 males) were included in the final analysis. Anti-TNF-α therapy was associated with improved health status and respiratory symptoms in 67.8% and 60.1% of cases, respectively. These results suggest that TNF-α inhibitors could be considered for the treatment of respiratory tract involvement of RP.