Open AccessExamining the associations among intraocular pressure, hepatic steatosis, and anthropometric parameters
Author(s) -
Ying-Jen Chen,
JiannTorng Chen,
MingCheng Tai,
Chang-Min Liang,
YuanYuei Chen,
TungWei Kao,
WenHui Fang,
WeiLiang Chen
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000017598
Subject(s) - medicine , steatosis , body mass index , anthropometry , waist , confidence interval , population , fatty liver , glaucoma , intraocular pressure , gastroenterology , ophthalmology , environmental health , disease
Emerging evidences had reported the positive relationship between obesity and intraocular pressure (IOP). The aim of the present study was to investigate the association between hepatic steatosis and IOP in an adult Taiwanese population. Seven thousand seven hundred twelve males and 6325 females who received a health examination at the Tri-Service General Hospital during the period from 2010 to 2016 were included in this study. IOP was measured by noncontact tonometry. Hepatic steatosis was diagnosed by abdominal ultrasound examination. Multivariate regression analyses were used to assess the associations among various anthropometric parameters and IOP. After adjusting for pertinent covariables, hepatic steatosis had a closer association with increased IOP than percentage body fat, body mass index, or waist circumference ( β = 0.017, 95% confidence interval [CI] = 0.006, 0.028). This relationship remained significant among males in the study population ( β = 0.015, 95% CI = 0.001, 0.029). Furthermore, hepatic steatosis was significantly correlated with increased risk of high IOP (odd ratios = 1.235, 95% CI = 1.041–1.465). Our study highlights that hepatic steatosis is a better index for assessing the relationship with increased IOP than other anthropometric parameters. Underlying pathophysiological mechanisms regulating the association between hepatic steatosis and increasing IOP and even the risk of glaucoma should be examined in further studies.