Open AccessClinical efficacy of weekly cisplatin for treatment of patients with breast cancer
Author(s) -
Ying Ma,
Nai-peng Zhang,
Ning An,
Wenyuan Li,
Wei Zhao,
Yan-cui Liu
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000017114
Subject(s) - medicine , cinahl , cochrane library , medline , psycinfo , randomized controlled trial , breast cancer , meta analysis , oncology , cancer , intensive care medicine , psychological intervention , psychiatry , political science , law
Background: We will investigate the efficacy and safety of weekly cisplatin (WC) for treatment of patients with breast cancer (BC) systematically. Methods: This study will describe and critically appraise shared decision approaches used in randomized controlled trials of WC for treatment of patients with BC. We will comprehensively search the following databases: PubMed, EMBASE, Web of Science, Cochrane Library, CINAHL, PsycINFO, Allied and Complementary Medicine Database, Wanfang, and Chinese Biomedical Literature Database from inception through July 1, 2019. We will utilize RevMan V.5.3 software (London, UK) for statistical analysis. Results: This study will systematically explore the efficacy and safety of WC for the treatment of patients with BC through evaluating primary outcomes of overall survival, pathological complete response; and secondary outcomes of cancer-specific survival, recurrence-free survival, disease-free survival, quality of life, and toxicities. Conclusion: This study will provide latest evidence of WC for the treatment of patients with BC. Systematic review registration: PROSPERO CRD42019145358.