Open AccessEfficacy of metoclopramide for the treatment of acute migraine
Author(s) -
Chao Jiang,
Ting Wang,
Zhengguo Qiu,
Bin Chen,
Bangjiang Fang
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000017065
Subject(s) - medicine , metoclopramide , cochrane library , migraine , medline , adverse effect , randomized controlled trial , meta analysis , clinical trial , political science , law , vomiting
Background: In this study, we will assess the efficacy and safety of metoclopramide for the treatment of acute migraine (AM). Methods: We will comprehensively search Cochrane Library, PUMBED, EMBASE, Google Scholar, Web of Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from the inception to July 1, 2019 to identify any eligible studies. Only randomized controlled trials will be considered for inclusion. The study selection, data collection, and management will be completed by two authors independently. The risk of bias will be assessed using Cochrane risk of bias tool. RevMan 5.3 software will be used for statistical analysis. Results: The primary outcome includes pain intensity, as measured by visual analogue scale or others. The secondary outcomes are success rate, requirement of rescue medicine, quality of life, relapse, and adverse events. Conclusions: This study will summarize the latest evidence for the clinical efficacy and safety of metoclopramide for the treatment of AM. PROSPERO registration number: PROSPERO CRD42019142795.