Open AccessOzone and pulsed electro-magnetic field therapies improve endometrial lining thickness in frozen embryo transfer cycles
Author(s) -
Zaher Merhi,
Rajean Moseley-LaRue,
Amber Ray Moseley,
André Hugo Smith,
Junyi Zhang
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000016865
Subject(s) - medicine , embryo transfer , endometrium , embryo , transdermal , infertility , andrology , ozone , gynecology , obstetrics , pregnancy , pharmacology , microbiology and biotechnology , biology , genetics , physics , meteorology
Rationale: In assisted reproductive technology, a persistently thin endometrial lining represents a huge challenge during frozen embryo transfer (FET) cycles. Patient concerns: Three patients who had a persistently thin endometrial lining despite the use of several medical agents known to improve endometrial lining thickness. Diagnoses: Infertility undergoing FET cycles. Interventions: A combination of transdermal and intravaginal ozone therapy along with Pulsed Electro-Magnetic Field (PEMF) therapy. Outcomes: Ozone with PEMF, both of which are known to have vasodilatatory, anti-inflammatory, and anti-oxidant actions, were successful in improving the thickness of the endometrial lining in all 3 patients. Two out of 3 patients became pregnant following single embryo transfer. Lessons: Ozone with PEMF constitute a novel experimental approach for women with persistently thin endometrial lining undergoing FET. This novel approach needs validation by large well-designed studies.