Open AccessEfficacy and safety of Tripterygium wilfordii Hook F preparations for the treatment of Crohn disease
Author(s) -
Jianying Zhang,
Gang Hou,
Zhenwei Yu
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000016231
Subject(s) - tripterygium wilfordii , medicine , meta analysis , medline , tripterygium , data extraction , cochrane library , intensive care medicine , alternative medicine , pathology , chemistry , organic chemistry , glycoside , political science , law
Background: Crohn disease (CD) is associated with substantial healthcare related costs and impairment of quality of life. Tripterygium wilfordii Hook F (TwHF) is proved to be effective for CD in animal and human. However, there is no systemic review and meta-analysis regarding the clinical efficacy and safety of TwHF preparation for the treatment of CD. Methods: Six electronic databases (Medline, EMBASE, Cochrane database, Chinese National Knowledge Infrastructure, Wanfang Database and Chongqing VIP Database) will be searched for eligibility studies. Data from the included studies will be extracted and the quality of studies will be assessed. Data synthesis will be performed using Review Manager software. Sensitivity analysis and publication bias assessment will also be carried out. Results: This systemic review and meta-analysis will provide synthesized result of clinical efficacy and safety of TwHF preparation for the treatment of CD. Conclusion: This research will determine the clinical efficacy and safety of TwHF preparation for the treatment of CD. Registration: PROSPERO CRD42019127893