Open AccessThe association of 6 variants of 8q24 and the risk of glioma
Author(s) -
Tong Yu,
Ye Lv,
Shiping Li,
Fengyan Zhao,
Junjie Ying,
Yi Qu,
Jinhui Li,
Dezhi Mu
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000016205
Subject(s) - glioma , medicine , genome wide association study , odds ratio , etiology , genetic association , oncology , genotype , genetics , bioinformatics , single nucleotide polymorphism , gene , biology , cancer research
With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 variants in 8q24 and glioma risk. Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 ( P = .003, odds ratio [OR] = 1.21), rs55705857 ( P = 2.31 × 10 –35 , OR = 3.54). In particular, both homozygous GG ( P = 1.91 × 10 –3 , OR1 = 2.01) and heterozygous GT ( P = 7.75 × 10 –10 , OR2 = 1.35) genotypes of rs4295627 were associated with glioma risk. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of glioma.