Open AccessModerate hypercapnia may not contribute to postoperative delirium in patients undergoing bronchoscopic intervention
Author(s) -
Qinghao Cheng,
Lei Li,
Mingyuan Yang,
Lei Sun,
Renjiao Li,
Rui Huang,
Jun Ma
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000015906
Subject(s) - medicine , hypercapnia , anesthesia , delirium , american society of anesthesiologists , sedation , prospective cohort study , emergence delirium , emergency department , point of delivery , surgery , intensive care medicine , acidosis , psychiatry , agronomy , biology
This study aimed to investigate the risk factors and whether acute hypercapnia contributes to postoperative delirium (POD) during bronchoscopic intervention under general anesthesia or deep sedation. A prospective study was conducted with 119 consecutive patients who had undergone bronchoscopic intervention between February 2016 and December 2016 at the Emergency General Hospital. Twenty-eight patients (23.8%) were diagnosed with POD. The patients were divided into 2 groups: the POD (n = 28) and the control group (n = 91). The mean age of the POD group was higher than that of the control group ( P < .01). All the blood gas values, PaCO 2 ( P < .01), PaO 2 ( P < .01), and PH ( P < .01), were significantly different. Multivariate analyses revealed that age ( P < .01), operation duration ( P = .01), and PO 2 ( P = .01) were independent predictive factors of POD, while hypercapnia ( P = .54) was established as not being a predictive factor of POD. Age, operation duration, and PO 2 were determined as independent predictive factors of POD, whereas moderate hypercapnia is not likely to contribute to POD in patients undergoing bronchoscopic intervention. Clinical Trial Registration Identifier: ChiCTR-POC-15007483.