Open AccessA case report dysregulated neutrophil extracellular traps in a patient with propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
Author(s) -
Kanako WatanabeKusunoki,
Nobuya Abe,
Daigo Nakazawa,
Kohei Karino,
Fumihiko Hattanda,
Yuichiro Fujieda,
S. Nishio,
Shinsuke Yasuda,
Akihiro Ishizu,
Tatsuya Atsumi
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000015328
Subject(s) - medicine , neutrophil extracellular traps , autoantibody , propylthiouracil , myeloperoxidase , pathogenesis , immunology , vasculitis , anti neutrophil cytoplasmic antibody , antibody , pathology , disease , inflammation , thyroid
Rationale: Neutrophil extracellular traps (NETs) are immune defence systems that release extracellular chromatin and myeloid granules including myeloperoxidase (MPO) to kill pathogens. An experimental animal study recently demonstrated that disordered NETs induced by propylthiouracil (PTU) could contribute to the production of MPO anti-neutrophil cytoplasmic antibody (ANCA) and the development of ANCA-associated vasculitis (AAV). However, the role of dysregulated NETs in the pathogenesis of human AAV remains unclear. Patient concerns: We report a 19-year-old woman with Graves’ disease on PTU presented fever, polyarthralgia, and lung hemorrhage with high titer of MPO-ANCA. This patient had a variety of atypical ANCAs and disordered NETs in vitro . Diagnoses: A diagnosis of PTU-induced AAV (PTU-AAV). Interventions: The PTU was discontinued and she was treated with immunosuppressants and plasmapheresis for reducing pathogenic autoantibodies. Outcomes: Clinical manifestations including fever, polyarthralgia, and lung hemorrhage were on remission with a decrease of dysregulated NETs. Lessons: The clinical course of this PTU-AAV case indicated that dysregulated NETs would play a role in the development of ANCA and the pathogenesis of AAV.