Open AccessMulti-b value diffusion-weighted magnetic resonance imaging and intravoxel incoherent motion modeling
Author(s) -
Chengcheng Liao,
YaZhen Qin,
Qi Tang,
Xiaohong Tan,
Qing Ke,
Yan Rong,
JianHong Zhong,
LeQun Li,
Hong Cen
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000014459
Subject(s) - intravoxel incoherent motion , medicine , magnetic resonance imaging , effective diffusion coefficient , nuclear medicine , diffusion weighted magnetic resonance imaging , cutoff , diffusion mri , chemotherapy , area under the curve , lymph , radiology , pathology , physics , quantum mechanics
The diagnostic efficiency of diffusion-weighted magnetic resonance imaging with different b -values and application of an intravoxel incoherent motion (IVIM) model for differentiating disease states of lymphoma was investigated. Thirty-six patients at initial diagnosis and 69 after chemotherapy underwent diffusion-weighted magnetic resonance imaging (DW-MRI) with multiple b -values. Analysis parameters included the apparent diffusion coefficient (ADC) for each b -value. Standard ADC, D , D ∗, and f were calculated using an IVIM model. For patients at initial diagnosis, compared with aggressive lymphomas, the benign lymph nodes exhibited higher mean ADC (2.34 vs 0.66 × 10 −3 mm 2 /s, P < .01) for b = 200 s/mm 2 . The AUC, sensitivity, specificity, and the cutoff value were 0.992, 96%, 100%, and 1.09 ×10 −3 mm 2 /s, respectively. For patients who had finished chemotherapy, the f -values of IVIM for those with partial remission (PR) were higher than those of complete remission (CR) (56.22 vs 21.81%, P < .01). The AUC, sensitivity, specificity, and the cutoff value were 0.937, 94%, 82%, 42.10%, respectively. For b = 200 s/mm 2 , ADC values are most helpful for characterizing benign lymph nodes and malignant lymphomas. The f -value of the IVIM is most valuable in the identification of residual lesions of lymphomas after chemotherapy.