Open AccessThe influence of obesity, smoking, and serum follicular stimulating hormone in azoospermic patients on testicular sperm extraction-intra cytoplasmic sperm injection outcomes
Author(s) -
Guy Shrem,
Yana Brudner,
Yuval Atzmon,
Mediea Michaeli,
A. Ellenbogen,
Einat Shalom-Paz
Publication year - 2019
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000014048
Subject(s) - medicine , testicular sperm extraction , intracytoplasmic sperm injection , azoospermia , sperm , andrology , pregnancy rate , gynecology , in vitro fertilisation , pregnancy , semen analysis , body mass index , male infertility , infertility , biology , genetics
To examine the effect of serum follicle-stimulating hormone (sFSH) level, body-mass index (BMI) and smoking on Testicular Sperm Extraction–Intracytoplasmic Sperm Injection (TESE–ICSI), and pregnancy outcomes. In this retrospective study, data were extracted from files of 52 azoospermic men who underwent TESE and in-vitro fertilization (IVF)-ICSI in our IVF unit. Demographic information, treatment cycle follow-up and pregnancy outcomes were collected. Fifty-two patients underwent 79 TESE due to azoospermia in 143 IVF cycles. Smoking was found to significantly affect sperm motility in TESE specimens before freezing (45.5% vs 14.8%; P <.001); however, this finding did not influence the pregnancy rate. Male FSH was inversely correlated with testicle volume (r = −0.595, P <.0001). Body weight did not affect semen parameters after TESE or ICSI outcomes. Among azoospermic patients with extremely poor sperm quality, male BMI, male FSH or smoking did not have an adverse effect sperm parameters or pregnancy and delivery rates.