Open AccessCoinfection with cryptococcus and aspergillus in an immunocompetent adult
Author(s) -
Qi Wang,
Zhaoyong Wang,
Yuqiu Hao,
Wei Li,
Xin Tong,
Mo Chen,
Peng Gao
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000012612
Subject(s) - medicine , cryptococcus , cryptococcus neoformans , aspergillus , coinfection , aspergillosis , lesion , pathological , cryptococcosis , surgery , microbiology and biotechnology , pathology , immunology , human immunodeficiency virus (hiv) , biology
Abstract Rationale: Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infection site is uncommon. This paper reports a case of healthy male who was diagnosed with both Cryptococcus neoformans and Aspergillus infections. Patient concerns: A healthy 33-year-old male office worker was admitted to the Second Hospital of Jilin University for hemoptysis. A chest computed tomography (CT) scan showed a cavity, which was formed by the thick dorsal wall of the lower left lobe with an irregular inner wall and burr changes around the lesion. Intervention: After 1.0 week of antibiotic and antituberculosis treatment, the hemoptysis symptoms remained. A resection of the left lower lobe was performed. Diagnoses: The postoperative pathological reports indicated the presence of both Aspergillus and Cryptococcus . The 2 fungal lesions were separate but within the same location. Outcomes: After treatment, the patient no longer had hemoptysis. Lessons: The current study indicated that fungi can infect not only immunocompromised patients but also healthy people, and that there can be 2 separate fungal infections at the same infection site.