Effect of successful revascularization on left ventricular diastolic dysfunction in patients with aortoiliac occlusive disease

Aortoiliac occlusive disease (AIOD) affects the systemic vascular resistance and increases the afterload because the left ventricle (LV) must work harder to eject blood into a smaller vascular bed. This study was to determine whether successful revascularization of AIOD is associated with improvement of left ventricular diastolic dysfunction (LVDD). A total of 37 patients with AIOD (34 men and 3 women; age 65.1 ± 7.2 years) were analyzed. The primary endpoint was defined as the change in the mitral E / E ′ ratio. There were no significant changes in the E velocity (from 0.7 ± 0.2 to 0.7 ± 0.2 m/s, P -value = .153), A velocity (from 0.8 ± 0.2 to 0.9 ± 0.2 m/s, P -value = .169), LAVI (from 36.1 ± 18.7 to 33.9 ± 15.7 mL/m 2 , P -value = .176), E / A ratio (from 0.9 ± 0.4 to 0.8 ± 0.2, P -value = .091), and E ′ velocity (from 6.5 ± 2.0 to 6.9 ± 2.1 m/s, P -value = .068). However, successful revascularization significantly reduced the E / E ′ ratio (from 14.1 ± 5.7 to 11.7 ± 3.3, P -value = .015). Additionally, a significant increase in the A ′ velocity (from 9.1 ± 1.9 to 10.0 ± 2.2 m/s, P -value = .029) and a decrease in the LA diameter (from 40.7 ± 6.4 to 38.6 ± 6.6 mm, P -value = .014) were noted. Our results show that a successful revascularization of AIOD was associated with an improved E / E ′ ratio.