Open AccessCumulative evidence for relationships between multiple variants in 8q24 and colorectal cancer incidence
Author(s) -
Tong Yu,
Huiqing Wang,
Shiping Li,
Fengyan Zhao,
Junjie Ying,
Yi Qu,
Dezhi Mu
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000011990
Subject(s) - colorectal cancer , medicine , genome wide association study , meta analysis , oncology , genotype , incidence (geometry) , etiology , cancer , genetics , bioinformatics , single nucleotide polymorphism , gene , biology , physics , optics
Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24. We conducted a comprehensive research synopsis and meta-analysis to evaluate associations between 6 variants in 8q24 and risk of colorectal cancer using data from 31 eligible articles totaling 41,942 cases and 49,968 controls. Of the 6 variants located in 8q24, 3 were significantly associated with risk of colorectal cancer. In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer. Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the exact role of the variants in the 8q24 involved in the etiology of colorectal cancer.