Open AccessMigraine as a risk factor for primary open angle glaucoma
Author(s) -
Chang Xu,
Jingjing Li,
Zhi Li,
Xiaogang Mao
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000011377
Subject(s) - medicine , meta analysis , migraine , risk factor , relative risk , glaucoma , cohort study , confidence interval , open angle glaucoma , ophthalmology
Migraine is increasingly being reported as a risk factor for primary open angle glaucoma (POAG). However, studies aimed to investigate this association yielded conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis. A systematic literature search from Embase, Web of Science, and PubMed was performed to identify relevant studies on the relationship between migraine and POAG. Random effects models were used to estimate the pooled relative risks (RRs) with 95% confidence intervals (95% CIs) in this meta-analysis. A total of 11 studies meeting the inclusion criteria were included in this meta-analysis. Our findings showed an RR of developing POAG of 1.24 (95% CI = 1.12–1.37) in migraine patients. No evidence of significant heterogeneity was detected across studies ( P = .071; I 2 = 41.7%). This association was not modified by the glaucoma type of the included patients. A significant association was observed in case–control design studies, but not in cohort design studies. Little evidence of publication bias was found. The findings of this meta-analysis suggest that migraine can significantly increase the risk of the development of POAG. However, the cohort study design failed to identify this association. Whether migraines can significantly increase the risk of developing POAG is still controversial.