Open AccessLow expression of long noncoding RNA MT1JP is associated with poor overall survival in gastric cancer patients
Author(s) -
Chenglou Zhu,
Jichun Ma,
Yaoqi Li,
Yongbin Zhang,
Mingxu Da
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000010394
Subject(s) - medicine , hazard ratio , confidence interval , meta analysis , cancer , oncology , cochrane library , long non coding rna , medline , prospective cohort study , rna , gene , biochemistry , chemistry , political science , law
Background: Although several researches have investigated the association between development and metastasis of gastric cancer (GC) and the expression level of MT1JP, there are no consensuses about whether its expression is associated with overall survival (OS) and clinical feature for GC patients. Methods: The databases including PubMed, EMBase databases, and the Cochrane Library were searched from inception to January 30, 2016, to identify the eligible studies. The quality of included studies was assessed according to reporting recommendations for tumor marker prognostic studies (REMARK). The association between expression level of LncRNA HOTAIR with OS for GC patients was assessed by calculating the pooled hazard ratio (HR) and 95% confidence interval (95% CI) using STATA version 12.0. Heterogeneity among studies will be assessed using the I 2 statistic. Results: Randomized controlled trials (RCTs), prospective cohort studies, and case–control studies will be used for the qualitative and quantitative synthesis of the meta-analysis to explore the association between MT1JP expression levels with OS for gastric cancer patients. Conclusion: We aim to draw an objective conclusion of the association between MT1JP expression levels with OS for gastric cancer patients.