Open AccessThe altered Granger causality connection among pain-related brain networks in migraine
Author(s) -
Yanzhe Ning,
Ruwen Zheng,
Kuangshi Li,
Yong Zhang,
Diyang Lyu,
Huang Jia,
Yi Ren,
Yihuai Zou
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000010102
Subject(s) - granger causality , migraine , aura , medicine , causality (physics) , resting state fmri , neuroscience , audiology , psychiatry , psychology , machine learning , computer science , physics , quantum mechanics , radiology
Numerous fMRI studies have confirmed functional abnormalities in resting-state brain networks in migraine patients. However, few studies focusing on causal relationships of pain-related brain networks in migraine have been conducted. This study aims to explore the difference of Granger causality connection among pain-related brain networks in migraine without aura (MWoA) patients. Twenty two MWoA patients and 17 matched healthy subjects were recruited to undergo resting-state fMRI scanning. Independent component analysis was used to extract pain-related brain networks, and Granger causality analysis to characterize the difference of Granger causality connection among pain-related brain networks was employed. Seven pain-related brain networks were identified, and MwoA patients showed more complex Granger causality connections in comparison with healthy subjects. Two-sample t test results displayed that there was the significant difference between right-frontoparietal network (RFPN) and executive control network (ECN). This study indicates that the specific intrinsic brain Granger causality connectivity among pain-related networks in MwoA patients are affected after long-term migraine attacks.