Open AccessBilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease
Author(s) -
Sandra Kurčová,
Jan Bardoň,
Miroslav Vaštík,
Marketa Vecerkova,
M. P. Frolova,
Lenka Hvizdošová,
Martin Nevrlý,
Kateřina Menšíková,
Pavel Otruba,
David Krahulík,
Egon Kurča,
Štefan Sivák,
Jana Zapletalová,
Petr Kaňovský
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000009750
Subject(s) - deep brain stimulation , subthalamic nucleus , medicine , parkinson's disease , rating scale , physical medicine and rehabilitation , disease , motor symptoms , physical therapy , psychology , developmental psychology
Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up. This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores ( P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores ( P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 ( P < .001); at Month 4, it remained significantly lower than before stimulation ( P = .036). There was no significant difference in The Parkinson's Disease Sleep Scaleat Month 1 and significant improvement at Month 4 ( P = .026). There were no significant changes in The Female Sexual Function Index or International Index of Erectile Function. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III scores show significant improvements at Month 1 ( P < .001) and at Month 4 ( P < .001). STN-DBS in patients with advanced PD clearly improves not only motor symptoms, but also several domains of nonmotor functions, namely sleep, autonomic functions and quality of life quickly following the start of stimulation.