Open AccessThe relationship between cognitive function and arterial partial pressure O2 in patients with COPD
Author(s) -
Xia-Hong Wen,
Yan Li,
Dong Han,
Sun Li,
Ping-Xiao Ren,
Deqing Ren
Publication year - 2018
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000009599
Subject(s) - medicine , copd , montreal cognitive assessment , cochrane library , meta analysis , cognition , confidence interval , subgroup analysis , physical therapy , cognitive impairment , psychiatry
Background: The high incidence of cognition disorders in chronic obstructive pulmonary disease (COPD) patients represents a main focus in public health field recently. Thus, we tried to explore relationship between cognitive function and arterial partial pressure O 2 (PaO 2 ) in patients with COPD as assessed by Mini-mental State Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA). Materials and methods: Medical and scientific literature databases, such as Web of Science, PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database, were searched independently by 2 reviewers until February 2016. Correlation coefficient ( r or r s ) values were obtained from each study, and 95% confidence intervals (CIs) were calculated using STATA12.0 software. Results: A total of 2049 studies were produced, and 9 of which were analyzed (714 participants) in the meta-analysis. The pooled r observed medium relationship for all selected studies ( r = 0.405, 95% CI 0.31–0.55), and notable heterogeneity was also tested between studies (χ 2 = 17.72, P = .023; I 2 = 54.9%). After the sensitivity and subgroup analysis, the heterogeneity significantly decreased. Subgroup analysis showed that MMSE score was stronger correlation between PaO 2 and cognitive function than MoCA score in the COPD patients. Begg test did not indicate potential risk of publication bias. Conclusions: There was a negative correlation between cognitive function and anoxia in patients with COPD, so it may be extremely essential to predict and improve the status of hypoxia in COPD patients.