Open AccessThe side effects and complications of percutaneous iodine-125 seeds implantation under CT-guide for patients with advanced pancreatic cancer
Author(s) -
WeiFu Lv,
D.S.K. Lu,
Jianghong Xiao,
Gauri Mukhiya,
Zhong-Xiao Tan,
Delei Cheng,
Chunze Zhou,
Xingmin Zhang,
Zhengfeng Zhang,
Chunmei Hou
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000009535
Subject(s) - medicine , vomiting , nausea , complication , perforation , incidence (geometry) , abdominal pain , percutaneous , pancreatic cancer , constipation , pancreatitis , surgery , side effect (computer science) , diarrhea , cancer , radiology , gastroenterology , materials science , computer science , optics , metallurgy , programming language , punching , physics
Purpose: The present study investigates the side effects and complications of computed tomography (CT)-guided percutaneous iodine-125 (I-125) seeds implantation for advanced pancreatic cancer. Methods: The clinical data were retrospectively analyzed for patients treated with implantation of I-125 seeds under CT-guide in our hospital from May 2010 to April 2015. The side effects and complications were collected and their possible reasons were analyzed. Results: A total of 78 patients were enrolled. The side effects were categorized as fever in 29 cases (37.18%), abdominal pain in 26 cases (33.33%), nausea and vomiting in 9 cases (11.54%), diarrhea in 5 cases (6.41%), and constipation in 4 cases (5.13%). Complications were composed of pancreatitis in 9 cases (11.54%), infection in 5 cases (6.41%), seed migration in 2 cases (2.56%), intestinal perforation in 1 case (1.28%), and intestinal obstruction in 1 case. The incidence of complication was 23.08% (18/78). The difference in incidence of complication was statistically significant between patients implanted with ≤27 seeds and those with >27 seeds ( P = .032). Conclusion: The side effects and complications frequently occur in implantation of I-125 seeds for patients with advanced pancreatic cancer. More concern should be given to the patients treated by this technique.