Open AccessIncreased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients
Author(s) -
Shinta Mizuno,
Masatoshi Wakui,
Yujiro Machida,
Naoki Hosoe,
Tadakazu Hisamatsu,
Takashi Ishida,
Kaori Kameyama,
Makoto Naganuma,
Takanori Kanai
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000009237
Subject(s) - medicine , prostaglandin e , gastroenterology , prostaglandin e2 , urinary system , panniculitis , inflammatory bowel disease , ulcerative colitis , metabolite , prostaglandin , pathology , disease
Rationale: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. Patient concern: In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels. Diagnoses: Mesenteric panniculitis Interventions: Both MP patients were measured the levels of PGE-MUM. Outcomes: Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids. Lessons: The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated.