Open AccessPrimary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Author(s) -
Wanlin Zhang,
Shuang Ma,
Lauren Havrilla,
Lin Cai,
Cheng-Qian Yu,
Shuai Shen,
HongTao Xu,
Liang Wang,
JuanHan Yu,
Xuyong Lin,
Endi Wang,
Lianhe Yang
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000008851
Subject(s) - medicine , thyroid , adenocarcinoma , oncology , dermatology , cancer
Rationale: Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignant nasopharyngeal tumor with features resembling papillary thyroid carcinoma including nuclear positive expression of thyroid transcription factor-1 (TTF-1). Patient concerns: A 64-year-old male presented with nasal bleeding and a foreign body sensation of the nasopharynx. Laryngoscopy revealed a 2.0-cm broad-based mass with a smooth surface on the posterior wall of the nasopharynx. A biopsy was obtained. Diagnoses: Histopathologic examination demonstrated tumor cells arranged in both papillary and glandular architecture. The tumor cells express nuclear immunoreactivity for TTF-1. The diagnosis of TL-LGNPPA was made. Interventions: After the patient was diagnosed with TL-LGNPPA, he underwent complete surgical resection. Outcomes: There was no recurrence or evidence of metastatic disease at the 12-month follow-up. Lessons: TL-LGNPPA is easy to misdiagnose as metastatic papillary thyroid carcinoma or other relative primary adenocarcinomas. It is important to have a broad differential diagnosis and know the key features of each entity because the prognosis and clinical treatment of each may differ.