Open AccessRetracted
Author(s) -
Wei Luo,
Ya-lun Li,
Ya Juan Chen,
Qing Xiang,
Hong Chen
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000008218
Subject(s) - medicine , carboplatin , nausea , radiation therapy , malignancy , chemotherapy , regimen , irinotecan , lung cancer , radiology , oncology , cancer , cisplatin , colorectal cancer
Rationale: Small cell lung cancer (SCLC) characterized by high degree of malignancy and rapid tumor progression. Intracranial metastases often appear at the time of the initial diagnosis or treatment. Besides of radiotherapy, chemotherapy is supposed to have limited effect. Patient concerns: A 66-year-old male had blurred vision and unsteady step with moderate headache, nausea, vomit. Diagnoses: The patient was diagnosed with SCLC with intracranial metastases. Interventions: High dose of nimustine (ACNU) (300 mg/m 2 ) add to the regimen containing carboplatin and irinotecan. Outcomes: Although the patient suffered severe myelosuppression, the intracranial lesion almost disappeared and maintained half a year. Lessons: ACNU at a dose of 200 mg/m 2 might be tolerable in combination with other chemotherapeutic drugs for the treatment of SCLC with intracranial metastases besides radiotherapy.