Open AccessAssociation between folate intake and risk of head and neck squamous cell carcinoma
Author(s) -
Chengchao Fan,
Siwei Yu,
Si Zhang,
Xiaojuan Ding,
Su Jing,
Zhiyong Cheng
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000008182
Subject(s) - medicine , head and neck squamous cell carcinoma , odds ratio , meta analysis , confidence interval , oncology , head and neck cancer , cancer
The results of published studies about the relationships between folate intake and risk of head and neck squamous cell carcinoma (HNSCC) remained inconsistent. Hence, a comprehensive and dose–response meta-analysis was performed to clarify the association between folate intake and HNSCC risk. The electric searches of Pubmed, Medline, and EMBASE databases were performed to identify the studies examining the relationship between folate intake and HNSCC risk on April 5, 2017. According to the inclusion criteria, finally 9 studies were included in this meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. Dose–response analysis was conducted to quantitate the relationship between dietary folate intake and HNSCC risk. The pooled OR for assessing the risk of HNSCC and folate intake in the highest level versus lowest level was 0.505 (95% CI 0.387–0.623). The linearity model of dose–response analysis indicated that with increased 100 μg/d folate intake, the risk of HNSCC decreased 4.3% degree (OR 0.957, 95% CI 0.935–0.980). These results indicate that folate is a protective nutrient against HNSCC carcinogenesis.