Open AccessA novel use of hill function and utility of 99mTc-MIBI scintigraphy to detect earlier lower extremity microvascular perfusion in patients with type 2 diabetes
Author(s) -
Yingsha Li,
Qiang Li,
Shen-Ju Liang,
Liang Xia,
Wen Zhou,
Hongbo He,
Rongbing Jin,
Kaifa Wang,
Zhiming Zhu,
Zhencheng Yan
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000008038
Subject(s) - medicine , perfusion , scintigraphy , diabetes mellitus , nuclear medicine , ankle , radiology , angiography , perfusion scanning , cardiology , surgery , endocrinology
We use the Hill function to analyze the dynamics of Tc-99m 2 methoxy-isobutyl-isonitrile ( 99m Tc-MIBI) scintigraphy data and to examine the earlier lower extremity microvascular perfusion of diabetic patients without typical clinical symptoms and with the preserved normal ankle-brachial index (ABI). Eighty-eight participants (30 healthy control, 34 diabetic patients, and 24 diabetic patients with peripheral arterial disease [PAD]) were recruited and applied 99m Tc-MIBI scintigraphy. Fourteen diabetic patients with PAD also underwent computed tomography angiography (CTA) examination and were performed endovascular interventions. Diabetic patients with normal ABI already have significantly impaired maximum 99m Tc-MIBI muscle perfusion counts ( P < .001) and the peak times of the lower extremity muscle perfusion ( P < .05). 99m Tc-MIBI scintigraphy showed great consistent with ABI and CTA in detecting PAD. 99m Tc-MIBI scintigraphy was also found to be effective in evaluating lower extremity circulation after endovascular interventions ( P < .05). Hill function-based analysis of 99m Tc-MIBI scintigraphy might be effective method to evaluate earlier lower extremity perfusion changes in diabetic patients.