Open AccessAssessment of optic disc and ganglion cell layer in diabetes mellitus type 2
Author(s) -
Evre Pekel,
Gökhan Tufaner,
Hüseyin Kaya,
Alper Kaşıkçı,
Gökhan Deda,
Gökhan Pekel
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000007556
Subject(s) - medicine , ophthalmology , nerve fiber layer , diabetic retinopathy , optic disc , retinal , ganglion cell layer , diabetes mellitus , ganglion , optical coherence tomography , inner plexiform layer , anatomy , endocrinology
The purpose of this study was to compare the optic disc parameters, retinal nerve fiber (RNFL), and macular ganglion cell layers between patients with diabetes mellitus (DM) type 2 and healthy controls. In this cross-sectional study, 69 eyes of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy controls were included. Optic disc parameters (i.e., rim area, disc area, cup to disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers (GCL + IPL) thickness were measured by means of spectral domain optical coherence tomography. There were not statistically significant differences between the diabetic patients and healthy controls in terms of RNFL thickness ( P = .32), rim area ( P = .20), disc area ( P = .16), cup volume ( P = .12), and average macular GCL + IPL thickness ( P = .11). Nevertheless, binocular RNFL thickness symmetry percentage ( P =.03), average cup to disc ratio ( P = .02), and superior-nasal macular GCL + IPL thickness ( P = .04) were statistically significantly different in the diabetic and control groups. Diabetic patients without retinopathy have more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner sectoral macular GCL + IPL when compared to healthy controls. Our results may support the statement that DM causes inner retinal neurodegenerative changes.