Open AccessA comparative study of Danhong injection and Salvia miltiorrhiza injection in the treatment of cerebral infarction
Author(s) -
Kaihuan Wang,
Dan Zhang,
Jiarui Wu,
Liyi Shi,
Xiaomeng Zhang,
Bing Zhang
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000007079
Subject(s) - medicine , salvia miltiorrhiza , cochrane library , confidence interval , adverse effect , meta analysis , randomized controlled trial , relative risk , medline , traditional chinese medicine , alternative medicine , pathology , political science , law
Background: To evaluate systematically the clinical effectiveness and safety of Danhong injection (DI) and Salvia miltiorrhiza injection (SMI) in the treatment of cerebral infarction. Methods: A literature search was conducted for retrieving randomized controlled trials (RCTs) on cerebral infarction treated by Danhong injection and SMI in the Cochrane Library, PubMed, Embase, China Biology Medicine disc, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database up to January 22, 2017. Two reviewers extracted information and independently assessed the quality of included RCTs by the Cochrane Risk of Bias Assessment Tool; then data were analyzed with Review Manager 5.3 software. Results: Twelve RCTs involving 1044 patients were included. The result of DI group was about 27% superior to SMI group in the clinical total effective rate (relative risk 1.27, 95% confidence interval 1.19–1.35, P < .00001). In addition, DI could prefect neurologic impairment (standardized mean difference −1.22, 95% confidence interval −1.90 to −0.54, P = .0004), and adjust hemorheological parameters. Three RCTs occurred 4 cases of adverse drug reactions/adverse drug events, but there were no serious adverse drug reactions/adverse drug events. Conclusion: Comparing with SMI combined with western medicine, DI combined with conventional therapy is more effective in improving the clinical total effective rate and neurologic impairment, but more evidence-based medicine research needed to support our study further.