Open AccessSerum apoprotein A1 levels are inversely associated with disease activity in gout
Author(s) -
Heqing Huang,
Bing Yu,
Wen Li,
Qingyan Lin,
Liying Chen,
Juan Chen,
Lihua Duan,
Guixiu Shi
Publication year - 2017
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000006780
Subject(s) - medicine , gout , erythrocyte sedimentation rate , ankylosing spondylitis , c reactive protein , gastroenterology , rheumatoid arthritis , serum amyloid a , spondyloarthropathy , osteoarthritis , lipid profile , inflammation , pathology , cholesterol , alternative medicine
To analyze the alteration of lipid profile and inflammatory markers in the serum of patients with gouty arthritis (GA), the levels of serum lipid profile, C-reactive protein (CRP), and erythrocyte sedimentation rates (ESRs) were measured in the serum of 69 gout patients, 35 patients with rheumatoid arthritis (RA), 23 patients with ankylosing spondylitis (AS)/spondyloarthropathy (SpA), and 25 patients with osteoarthritis (OA). The serum levels of apoprotein A1 (Apo-A1) were significantly decreased in patients with gout when compared with RA, AS/SpA, and OA patients. The serum levels of CRP were significantly increased in gouty patients when compared with RA, AS/SpA, and OA patients. Furthermore, the serum levels of ESR were significantly increased in patients with gout compared to patients with OA. Correlation analysis indicated that the levels of Apo-A1 were negatively correlated with serum ESR and CRP ( r = −0.475, P < .001; r = −0.380, P = .001, respectively) in the patients with GA. Taken together, this study gives us a better understanding of the relationships between serum lipid profile and inflammatory markers in gout patients.