Open AccessMultifocal extranodal lymphoma
Author(s) -
Chao Li,
Li Lin,
Ping Zhang,
Jinsong Zhang,
Ting Gao,
Yan Xu,
Wen-Chan Li
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000005029
Subject(s) - medicine , rituximab , lymphoma , vincristine , positron emission tomography , radiology , positron emission tomography computed tomography , cyclophosphamide , prednisolone , biopsy , chemotherapy , pathology
We report an unusual and interesting case of non-Hodgkin lymphoma involving 7 extranodal sites. In this case, a 43-year-old woman with diffuse large B-cell lymphoma, including stomach, breasts, pancreas, adrenal glands, ovary and bones, was confirmed by biopsy and positron emission tomography/computed tomography scan. The patient achieved a complete response after 2 cycles of chemotherapy with combined rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone, but subsequently developed central nervous system involvement. Conclusion: This case illustrated the usefulness of positron emission tomography/computed tomography in diagnosis, disease staging, and assessment of response to therapy. Selection of the optimal treatment regimen is challenging and needs further research.