Open AccessDetection of chronic brain damage by diffusion-weighted imaging with multiple b values in patients with type 2 diabetes
Author(s) -
Tieli Liu,
Yemei Han,
Tang Lemei,
Jianlin Wu,
Yanwei Miao,
Bingbing Gao,
Jin Shang
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000004726
Subject(s) - medicine , receiver operating characteristic , effective diffusion coefficient , leukoaraiosis , nuclear medicine , magnetic resonance imaging , diffusion mri , atrophy , white matter , cardiology , radiology
The aim of the study was to evaluate the performance of parameters obtained from diffusion-weighted imaging (DWI) with multiple b values in the detection of chronic brain damage in patients with type 2 diabetes. We enrolled 30 patients with or without abnormalities on brain magnetic resonance imaging (lacunar infarction, leukoaraiosis, and/or brain atrophy) and 15 nondiabetic controls; obtained DWI parameters that included apparent diffusion coefficient (ADC), fast ADC (ADC fast ), slow ADC (ADC slow ), fraction of fast ADC ( f ), distributed diffusion coefficient (DDC), and stretched exponential (α); and performed receiver operating characteristic (ROC) analysis to evaluate the performance of parameters for the detection of chronic brain damage. The parameters ADC, ADC slow , f , and DDC were increased, whereas parameters ADC fast and α were decreased in type 2 diabetes patients compared with controls without diabetes. The centrum semiovale showed the most significant change in the evaluated parameters, and the changes in parameters ADC slow , f , and DDC were greater than the changes in other parameters. There was no significance between parameters of the biexponential model (ADC fast , ADC slow , f ) and parameters of the stretched model (DDC, α), but parameters of both these models were superior to the parameter of monoexponential model (ADC). Moreover, ROC analysis showed that ADC slow of the centrum semiovale supplied by the anterior cerebral artery had the highest performance for detection of chronic brain damage (area under the ROC curve of 0.987, 93.3% sensitivity, and 100% specificity). Our study shows that DWI with multiple b values can quantitatively access chronic brain damage and may be used for detection and monitoring in type 2 diabetes patients.