Open AccessEpidemiology of Glomerular Disease in Southern Arizona
Author(s) -
Sangeetha Murugapandian,
Iyad Mansour,
Mohammad Hudeeb,
Khaled Muhammed Souliman Hamed,
Emad Hammode,
Babitha Bijin,
Sepehr Daheshpour,
Bijin Thajudeen,
Pradeep V. Kadambi
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000003633
Subject(s) - lupus nephritis , medicine , focal segmental glomerulosclerosis , glomerulonephritis , membranous nephropathy , nephropathy , pathology , renal biopsy , minimal change disease , population , kidney disease , systemic lupus erythematosus , nephritis , biopsy , disease , kidney , endocrinology , diabetes mellitus , environmental health
Glomerulonephritis stands third in terms of the etiologies for end-stage kidney disease in the USA. The aim of this study was to look at the patterns of biopsy-proven glomerulonephritis based on data from a single center. Kidney biopsy specimens of all patients above the age of 18 years, over a 10-year period, who had diagnosis of nondiabetic glomerular disease, were selected for the study. The most common histopathological diagnosis was focal and segmental glomerulosclerosis (FSGS) (22.25%, 158/710) followed by membranous nephropathy (20.28%, 144/710) and immunoglobulin (Ig)A nephropathy (19.71%, 140/710). There was male preponderance in all histological variants except IgA nephropathy, lupus nephritis, and pauci-immune glomerulonephritis. The race distribution was uneven, and all histological variants, except minimal change disease and lupus nephritis, were more commonly seen in whites. In a separate analysis of the histological pattern in Hispanics, lupus nephritis was the most common pathology (28.70%, 62/216) followed by FSGS (18.05%, 39/216). In American Indian population, the most common pathology was IgA nephropathy (33.33%, 8/24) followed by FSGS (16.67%, 4/24). This study highlights the histopathological patterns of glomerular disease in southern Arizona. The data suggest regional and ethnic variations in glomerular disease that may point towards genetic or environmental influence in the pathogenesis of glomerular diseases.