Open AccessDiagnostic Performances of 99mTc-Methoxy Isobutyl Isonitrile Scan in Predicting the Malignancy of Lung Lesions
Author(s) -
Zhang Shuxin,
Yang Liu
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000003571
Subject(s) - medicine , confidence interval , malignancy , receiver operating characteristic , meta analysis , funnel plot , nuclear medicine , odds ratio , publication bias , lung cancer , diagnostic odds ratio , likelihood ratios in diagnostic testing , radiology , area under the curve , lung
We performed a meta-analysis to evaluate the value of technetium-99m methoxy isobutyl isonitrile ( 99m Tc-MIBI) single photon emission computed tomography (SPECT) in differentiating malignant from benign lung lesions. The PubMed and Embase databases were comprehensively searched for relevant articles that evaluated lung lesions suspicious for malignancy. Two reviewers independently extracted the data on study characteristics and examination results, and assessed the quality of each selected study. The data extracted from the eligible studies were assessed by heterogeneity and threshold effect tests. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and areas under the summary receiver-operating characteristic curves (SROC) were also calculated. Fourteen studies were included in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio, and DOR of 99m Tc-MIBI scan in detecting malignant lung lesions were 0.84 (95% confidence interval [CI]: 0.81, 0.87), 0.83 (95% CI: 0.77, 0.88), 4.22 (95% CI: 2.53, 7.04), 0.20 (95% CI: 0.12, 0.31), and 25.71 (95% CI: 10.67, 61.96), respectively. The area under the SROC was 0.9062. Meta-regression analysis showed that the accuracy estimates were significantly influenced by ethnic groups ( P < 0.01), but not by image analysis methods, mean lesion size, or year of publication. Deek funnel plot asymmetry test for the overall analysis did not raise suspicion of publication bias ( P = 0.50). Our results indicated that 99m Tc-MIBI scan is a promising diagnostic modality in predicting the malignancy of lung lesions.