Open AccessCEA Level, Radical Surgery, CD56 and CgA Expression Are Prognostic Factors for Patients With Locoregional Gastrin-Independent GNET
Author(s) -
Yuan Li,
Xinyu Bi,
Jianjun Zhao,
Zhen Huang,
Junhu Zhou,
Zhiyu Li,
Yefan Zhang,
Muxing Li,
Xiao Chen,
Xuhui Hu,
Yue Chi,
Dongbing Zhao,
Hong Zhao,
Jianqiang Cai
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000003567
Subject(s) - medicine , gastrin , interquartile range , carcinoembryonic antigen , univariate analysis , lymphadenectomy , gastroenterology , radical surgery , multivariate analysis , pathological , retrospective cohort study , oncology , cancer , secretion
Gastrin-independent gastric neuroendocrine tumors (GNETs) are highly malignant. Radical resections and lymphadenectomy are considered to be the only possible curative treatment for these tumors. However, the prognosis of gastrin-independent GNETs is not well defined. In this study, we identified prognostic factors of locoregional gastrin-independent GNETs. All patients diagnosed with locoregional gastrin-independent GNETs between 2000 and 2014 were included in this retrospective study. Clinical characteristics, blood tests, pathological characteristics, treatments, and follow-up data of the patients were collected and analyzed. Of the 66 patients diagnosed with locoregional gastrin-independent GNETs, 57 (86.4%) received radical resections, 7 (10.6%) with palliative resection, 1 (1.5%) with gastrojejunostomy, and 1 (1.5%) with exploration surgeries. The median survival time for these patients was 19.0 months (interquartile range, 11.0–38.0). The 1-, 3-, and 5-year survival rates were 72%, 34%, and 28%, respectively. Multivariate analysis indicated that carcinoembryonic antigen (CEA) level ( P = 0.04), radical resection ( P = 0.04), and positive Cluster of Differentiation 56 (CD56) expression ( P = 0.016) were significant prognostic factors on overall survival rate. Further univariate and multivariate analysis of 57 patients who received radical resections found that CgA expression ( P = 0.35) and CEA level ( P = 0.33) are independent prognostic factors. Gastrin-independent GNETs had poor prognosis. Serum CEA level, radical surgery, CD56 and CgA expression are markers to evaluate the survival of patients with locoregional gastrin-independent GNETs.