Open AccessA Successfully Treated Metastatic Choriocarcinoma Coexistent With Pregnancy
Author(s) -
Panxi Yu,
Wenqi Diao,
Xuefeng Jiang
Publication year - 2016
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000003505
Subject(s) - medicine , choriocarcinoma , pregnancy , obstetrics , gestation , chorioepithelioma , chemotherapy , human chorionic gonadotropin , vaginal bleeding , metastasis , gestational age , pathological , gynecology , trophoblastic tumor , cancer , surgery , hormone , genetics , biology
Gestational choriocarcinoma ended with a successful parturition is extremely rare, especially in cases where multiple metastases occurred. A 29-year-old Chinese primigravida was admitted with vaginal bleeding at 32 +2 gestational week, and diagnosed with gestational choriocarcinoma with vaginal, pulmonary, and cerebral metastasis after pathological, and imaging examination. At 33 +1 gestational week, a healthy infant was delivered by cesarean section. Although no evidence of choriocarcinoma or any other forms of gestational trophoblastic diseases was found in the placenta and uterine curettages, the patient was given 7 cycles of postpartum chemotherapy. Her serum beta-human chorionic gonadotropin level fell to the normal range, and the metastatic lesions reduced. The baby is still free from diseases, and the patient reports no clinical manifestation 4 years after the hospital discharge. Despite its rapid metastases and complications, gestational choriocarcinoma still can be successfully treated by postpartum chemotherapy with the least delay.