Open AccessKinetic Changes of Viremia and Viral Antigens of Hepatitis B Virus During and After Pregnancy
Author(s) -
Jingli Liu,
Yongchun Bi,
Chenyu Xu,
Lanhua Liu,
Biao Xu,
Tingmei Chen,
Jie Chen,
Mingjie Pan,
Yali Hu,
YiHua Zhou,
Jingli Liu,
Jingli Liu,
Jingli Liu,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Yongchun Bi,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Chenyu Xu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Lanhua Liu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Biao Xu,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Tingmei Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Jie Chen,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Mingjie Pan,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
Yali Hu,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou,
YiHua Zhou
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000002001
Subject(s) - hbeag , medicine , hbsag , pregnancy , hepatitis b virus , viremia , antigen , hepatitis b , virology , immunology , virus , biology , genetics
Whether pregnancy may influence the replication of hepatitis B virus (HBV) remains unknown. The authors aimed to clarify this issue by observing the kinetics of HBV deoxyribonucleic acid (DNA) and viral antigens in women during and after pregnancy. Total, 371 pregnant women with positive hepatitis B surface antigen (HBsAg) were enrolled. Serial sera collected during and after pregnancy were quantitatively measured for HBV DNA, HBsAg, and hepatitis B e antigen (HBeAg). Total, 34 HBeAg-positive women underwent alanine aminotransferase (ALT) elevation during or after pregnancy; levels of HBV DNA and HBsAg in them showed no obvious change between second trimester or delivery and 7 to 12 months postpartum ( P > 0.05). The 337 others had normal alanine aminotransferase levels during pregnancy and postpartum. In 147 HBeAg-positive women with follow-up 7 to 12 months postpartum, the average levels of HBV DNA (>7.0 log 10 IU/mL), HBsAg (>4.0 log 10 IU/mL), and HBeAg (>3.0 log 10 S/CO) were longitudinally constant during pregnancy and postpartum, respectively. In 173 women with follow-up 4.8 years postpartum, neither HBV DNA levels nor antigen titers showed significant difference between second trimester and 4.8 years postpartum, regardless of the HBeAg status. In addition, levels of HBV DNA and viral antigens in second trimester, around delivery, 6 to 8 weeks and 7 to 12 months postpartum showed no marked fluctuations, respectively. Serum levels of HBV DNA and viral antigens in HBsAg-positive women are highly constant during pregnancy and postpartum, regardless of the HBeAg status and alanine aminotransferase levels. This demonstrates that pregnancy has little influence on the HBV replication and antigen expression.