Open AccessFrontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease
Author(s) -
Hyun Woong Roh,
Chang Hyung Hong,
Soojin Lee,
Yunhwan Lee,
Kang Soo Lee,
Ki Jung Chang,
Byoung Hoon Oh,
Seong Hye Choi,
Seong Yoon Kim,
Joung Hwan Back,
Young Ki Chung,
Ki Young Lim,
Jai Sung Noh,
Sang Joon Son
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001918
Subject(s) - medicine , hazard ratio , hip fracture , stroop effect , proportional hazards model , confidence interval , dementia , frontal lobe , physical therapy , osteoporosis , psychiatry , disease , cognition
To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD). Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included. A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline. After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory, and attention), the Cox proportional hazard regression analysis revealed that risk of a hip fracture was decreased with a hazard ratio (HR) of 0.98 per one point of increase in the Stroop Test (adjusted HR = 0.98, 95% confidence interval [CI]: 0.97–1.00) and 0.93 per one point increase in COWAT (adjusted HR = 0.93, 95% CI: 0.88–0.99). The risk of hip fracture in AD patients was associated with baseline frontal lobe function. The result of this research presents evidence of association between frontal lobe function and risk of hip fracture in patients with AD.