Open AccessSerum Phosphorylated Neurofilament-Heavy Chain, a Potential Biomarker, is Associated With Peripheral Neuropathy in Patients With Type 2 Diabetes
Author(s) -
Xuguang Qiao,
Shuo Zhang,
Weiwei Zhao,
Hongying Ye,
Yehong Yang,
Zhaoyun Zhang,
Qing Miao,
Renming Hu,
Yiming Li,
Bin Lü
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001908
Subject(s) - medicine , odds ratio , quartile , peripheral neuropathy , creatinine , type 2 diabetes , diabetes mellitus , confidence interval , endocrinology , biomarker , renal function , diabetic neuropathy , gastroenterology , neurofilament , confounding , hemoglobin , immunohistochemistry , biochemistry , chemistry
Neurofilament (NF), one of the major axonal cytoskeletal proteins, plays a critical role in degenerative diseases in both the central and the peripheral nervous systems. The aim of this study is to explore the relationship between serum phosphorylated neurofilament-heavy chain (pNF-H) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes. Serum pNF-H concentrations were measured by ELISA in hospitalized patients with and without DPN (n = 118). DPN was assessed by clinical symptoms, signs, and electromyography. Compared with the non-DPN group (311.98 [189.59–634.12] pg/mL), the confirmed group (605.99 [281.17–1332.78] pg/mL) patients had the higher serum pNF-H levels ( P = 0.007). DPN was significantly correlated with C-peptide ( r = −0.269), total cholesterol (TC) ( r = 0.185), and pNF-H ( r = 0.258). Serum pNF-H levels were independently associated with DPN ( P = 0.004), even after adjusting for age, sex, duration of diabetes, fasting plasma glucose, glycosylated hemoglobin A 1c , TC, C-peptide, urinary albuminto/creatinine ratio, and estimated glomerular filtration rate. Compared with pNF-H quartile 1 (referent), patients in quartile 3 (odds ratio [OR], 3.977; 95% confidence interval [CI], 1.243–12.728; P = 0.021) and quartile 4 (OR, 10.488; 95% CI, 3.020–34.429; P = 0.000) had the higher risk of DPN after adjusting for the confounders. Serum pNF-H levels might be associated with the DPN, and the correlationship between serum pNF-H and DPN should be further studied.