Open AccessModified Glasgow Prognostic Score is Associated With Risk of Recurrence in Bladder Cancer Patients After Radical Cystectomy
Author(s) -
Matteo Ferro,
Ottavio De Cobelli,
Carlo Buonerba,
Giuseppe Di Lorenzo,
Marco Capece,
Dario Bruzzese,
Riccardo Autorino,
Danilo Bottero,
Antonio Cioffi,
Deliu Victor Matei,
Michele Caraglia,
Marco Borghesi,
Ettore De Berardinis,
Gian Maria Busetto,
Riccardo Giovan,
Giuseppe Lucarelli,
Pasquale Ditonno,
Sisto Perdonà,
Pierluigi Bove,
Luigi Castaldo,
Rodolfo Hurle,
Gennaro Musi,
Antonio Brescia,
Michele Olivieri,
Amelia Cimmino,
Vincenzo Altieri,
Rocco Damiano,
Francesco Cantiello,
Vincenzo Serretta,
Sabino De Placido,
Vincenzo Mirone,
Guru Sonpavde,
Daniela Terracciano
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001861
Subject(s) - medicine , bladder cancer , cystectomy , hazard ratio , proportional hazards model , cohort , multivariate analysis , stage (stratigraphy) , cancer , gastroenterology , univariate analysis , oncology , confidence interval , paleontology , biology
Recently, many studies explored the role of inflammation parameters in the prognosis of urinary cancers, but the results were not consistent. The modified Glasgow Prognostic Score (mGPS), a systemic inflammation marker, is a prognostic marker in various types of cancers. The aim of the present study was to investigate the usefulness of the preoperative mGPS as predictor of recurrence-free (RFS), overall (OS), and cancer-specific (CSS) survivals in a large cohort of urothelial bladder cancer (UBC) patients. A total of 1037 patients with UBC were included in this study with a median follow-up of 22 months (range 3–60 months). An mGPS = 0 was observed in 646 patients (62.3%), mGPS = 1 in 297 patients (28.6 %), and mGPS = 2 in 94 patients (9.1%). In our study cohort, subjects with an mGPS equal to 2 had a significantly shorter median RFS compared with subjects with mGPS equal to 1 (16 vs 19 months, hazard ratio [HR] 1.54, 95% CI 1.31–1.81, P < 0.001) or with subjects with mGPS equal to 0 (16 vs 29 months, HR 2.38, 95% CI 1.86–3.05, P < 0.001). The association between mGPS and RFS was confirmed by weighted multivariate Cox model. Although in univariate analysis higher mGPS was associated with lower OS and CSS, this association disappeared in multivariate analysis where only the presence of lymph node-positive bladder cancer and T4 stage were predictors of worse prognosis for OS and CSS. In conclusion, the mGPS is an easily measured and inexpensive prognostic marker that was significantly associated with RFS in UBC patients.