Open AccessCase Report
Author(s) -
Michael Krakau,
Kathrin Gerbershagen,
Ulrich Frost,
Markus Hinzke,
Michael Brockmann,
Verena Schildgen,
Axel Gomann,
Volker Limmroth,
Arno J. Dormann,
Oliver Schildgen
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001587
Subject(s) - medicine , context (archaeology) , pneumonia , bronchoalveolar lavage , human bocavirus , disease , respiratory disease , intensive care unit , stroke (engine) , pediatrics , intensive care medicine , immunology , respiratory system , respiratory tract infections , lung , mechanical engineering , paleontology , engineering , biology
Although the human bocavirus (HBoV) is known since a decade, limited information about its pathogenesis is available due to the lack of an animal model. Thus, clinical cases and studies are the major source of novel information about the course of infection and the related pathophysiology. In this context, a clinical case of an adult patient suffering from severe HBoV-pneumonia is described that was associated with loss of consciousness followed by acute rib fracture and subsequent neurological disorder. Following initial global respiratory dysfunction the clinical respiratory symptoms recovered but the neurological symptoms maintained after weaning and intensive care in the stroke unit. During the initial phase, an acute active HBoV infection was confirmed by positive polymerase chain reactions from bronchoalveolar lavage fluid and serum. The case further demonstrates that HBoV can cause severe pneumonia, induce secondary disease also in adults, and may be associated with neurological symptoms as previously assumed.