Open AccessLow Expression of LDHB Correlates With Unfavorable Survival in Hepatocellular Carcinoma
Author(s) -
Ruohua Chen,
Xiang Zhou,
Zhenhai Yu,
Jianjun Liu,
Gang Huang,
Ruohua Chen,
Ruohua Chen,
Ruohua Chen,
Ruohua Chen,
Ruohua Chen,
Ruohua Chen,
Ruohua Chen,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Xiang Zhou,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Zhenhai Yu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Jianjun Liu,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang,
Gang Huang
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001583
Subject(s) - medicine , hepatocellular carcinoma , immunohistochemistry , proportional hazards model , pathology , survival analysis , metastasis , lactate dehydrogenase , pathological , cancer , lymph node , cancer research , oncology , biology , enzyme , biochemistry
Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and plays important roles in the development of human cancers. However, the association between LDHB expression and the clinicopathological characteristics of hepatocellular carcinoma (HCC) is not well understood. The study was to detect the expression of LDHB in human HCC and investigate the association between its expression and the clinicopathological characteristics of HCC. Immunohistochemistry (IHC) analysis was performed to characterize the expression of LDHB in HCC and matched noncancerous tissues. Kaplan–Meier survival and Cox regression analyses were employed to evaluate the prognosis of 75 HCC patients. The results showed that the expression of LDHB in HCC was significantly lower than that in noncancerous tissues. Moreover, the expression level of the LDHB protein in HCC was correlated with pathological grade ( P = 0.037), vascular invasion ( P = 0.037), lymph node metastasis ( P = 0.016), and tumor-node metastasis (TNM) stage ( P = 0.007). Cox regression analysis further revealed that LDHB expression is an independent prognostic factor for disease-free survival ( P = 0.045) and overall survival ( P = 0.019). These data are the first to indicate that LDHB expression is a valuable prognostic biomarker for HCC and that low LDHB expression suggests unfavorable survival outcomes in HCC patients.