Open AccessSuccessful Pregnancy Following Assisted Reproduction in Woman With Systemic Lupus Erythematosus and Hypertension
Author(s) -
José Fernando de Macedo,
Gustavo Capinzaiki de Macedo,
Luciana Aparecida Campos,
Ovidiu Constantin Baltatu
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000001531
Subject(s) - medicine , pregnancy , prednisone , miscarriage , obstetrics , antiphospholipid syndrome , lupus erythematosus , anti nuclear antibody , intrauterine growth restriction , systemic lupus erythematosus , fetus , immunology , thrombosis , antibody , autoantibody , disease , genetics , biology
Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a patient with systemic lupus erythematosus and hypertension. A 39-year-old nulliparous woman presented with systemic lupus erythematosus with antinuclear and antiphospholipid antibodies, hypertension and recurrent pregnancy loss presented for assisted reproduction. The patient responded well to enoxaparin and prednisone during both assisted reproduction and prenatal treatment. This case report indicates that prescription of immunosuppressant and blood thinners can be safely recommended throughout the whole prenatal period in patients with systemic lupus erythematosus. Enoxaparin and prednisone may be prescribed concurrently during pregnancy.