Open AccessQuality of Life After Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism
Author(s) -
ShihPing Cheng,
Jie-Jen Lee,
Tsang-Pai Liu,
PoSheng Yang,
Sung-Chen Liu,
YenChu Hsu,
ChienLiang Liu,
ShihPing Cheng,
ShihPing Cheng,
ShihPing Cheng,
ShihPing Cheng,
ShihPing Cheng,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Jie-Jen Lee,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
Tsang-Pai Liu,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
PoSheng Yang,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
Sung-Chen Liu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
YenChu Hsu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu,
ChienLiang Liu
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000000931
Subject(s) - medicine , asymptomatic , quality of life (healthcare) , parathyroidectomy , confidence interval , strictly standardized mean difference , randomized controlled trial , primary hyperparathyroidism , meta analysis , physical therapy , hyperparathyroidism , pediatrics , nursing , parathyroid hormone , calcium
A number of studies have investigated the effects of surgery on symptoms and quality of life in patients with hyperparathyroidism. However, the results are inconsistent. We conducted this meta-analysis to quantitatively assess changes in quality of life among patients with asymptomatic primary hyperparathyroidism. Different databases were searched for randomized controlled trials comparing surgery with surveillance. Quality of life was measured by the Short Form-36 general health survey. The pooled random-effects estimates of standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated. Three trials involving 294 participants were included. At 1 year, patients undergoing parathyroidectomy had significantly better physical role functioning (SMD, 0.31; 95% CI 0.04–0.57; P = 0.02) and emotional role functioning (SMD, 0.29; 95% CI 0.02–0.55; P = 0.03). At 2 years, the surgery group had significantly better emotional role functioning (SMD, 0.35; 95% CI 0.02–0.67; P = 0.04) than the surveillance group. Furthermore, compared with baseline, emotional role functioning improved after surgery (SMD, 0.31; 95% CI 0.02–0.60; P = 0.04), whereas emotional role functioning tended to get worse in patients assigned to medical surveillance (SMD, −0.27; 95% CI −0.55 to 0.02; P = 0.07). Although Short Form-36 is a generic instrument, our results suggest that parathyroidectomy may be associated with better quality of life, especially in the emotional aspects of well-being.