Open AccessCharacterization of Papillary Thyroid Microcarcinomas Using Sonographic Features in Malignant Papillary Thyroid Cancer
Author(s) -
Weijun Gu,
Hong Yan,
Yukun Luo,
Fulin Wang,
Guoqing Yang,
Qinghua Guo,
Nian Jin,
Li Zang,
Kang Chen,
Jin Du,
Xian-ling Wang,
Lijuan Yang,
Jianming Ba,
Jingtao Dou,
Yiming Mu,
Changyu Pan,
Zhaohui Lv,
Hong Yan,
Hong Yan,
Hong Yan,
Hong Yan,
Hong Yan,
Hong Yan,
Hong Yan,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Yukun Luo,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Fulin Wang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Guoqing Yang,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Qinghua Guo,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Nian Jin,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Li Zang,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Kang Chen,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Jin Du,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Xian-ling Wang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Lijuan Yang,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jianming Ba,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Jingtao Dou,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Yiming Mu,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Changyu Pan,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv,
Zhaohui Lv
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000000841
Subject(s) - medicine , thyroid nodules , malignancy , thyroid , radiology , thyroid carcinoma , differential diagnosis , nodule (geology) , papillary thyroid cancer , pathological , retrospective cohort study , thyroid cancer , thyroidectomy , ultrasonography , pathology , paleontology , biology
The diagnosis of malignant thyroid nodules is still a clinical challenge. This study aimed to determine the ultrasonographic characteristics of papillary thyroid carcinoma. The ultrasonographic and pathological data of 2453 thyroid nodules in a cohort of 1895 Chinese patients who underwent thyroidectomy from January 2010 to December 2012 were retrospectively reviewed. Anteroposterior and transversal (AP/TR) diameters ≥1, solid structure, infiltrative margins, hypoechoic appearance, and microcalcifications were more common in malignant nodules than in benign nodules ( P < 0.01). These ultrasonographic features were independent risk factors of malignancy ( P < 0.01) as determined by logistic regression analysis. Based on multivariate analysis, these characteristics were also present in large nodules (diameter >10 mm). However, in small nodules (diameter ≤10 mm), only AP/TR ≥1 and infiltrative margins were independent risk factors of malignancy ( P < 0.01). Ultrasonography is of high diagnostic value for malignant thyroid nodules and may help to improve the differential diagnosis. Small and large nodules have distinct ultrasonographic features.