Open AccessAn Elevated Percentage of Reticulated Platelet Is Associated With Increased Mortality in Septic Shock Patients
Author(s) -
Qin Wu,
Jianan Ren,
Dong Hu,
Pengjun Jiang,
Guanwei Li,
Nadeem Anjum,
Gefei Wang,
Guosheng Gu,
Jun Chen,
Xiuwen Wu,
Song Liu,
Yuan Li,
Yunzhao Zhao,
Jieshou Li,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Jianan Ren,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Dong Hu,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Pengjun Jiang,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Guanwei Li,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Nadeem Anjum,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Gefei Wang,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Guosheng Gu,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Jun Chen,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Xiuwen Wu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Song Liu,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yuan Li,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Yunzhao Zhao,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li,
Jieshou Li
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000000814
Subject(s) - medicine , septic shock , prospective cohort study , sepsis , confounding , logistic regression , shock (circulatory) , receiver operating characteristic , surgery
Microcirculatory changes and coagulation disturbances are thought to play a key role in sepsis. Some evidence suggests that the percentage of reticulated platelets (RP%) may be a valuable and cost-effective sepsis screening parameter. This was a prospective study in surgical patients to investigate the potential value of RP% as a predictor of mortality in septic shock patients. This was a prospective study conducted in a surgical critical care center of a Chinese tertiary care hospital. Consecutive septic shock patients were enrolled at admission. Age- and sex-matched non-septic patients were recruited as control patients. RP% was determined by flow cytometry in 68 septic shock patients and 68 controls. Compared with survivors, septic patients who died presented with a significantly higher RP% ( P < 0.001). The area under the receiver-operating characteristic curve for the RP% association with mortality was 0.867 (95 % CI 0.780–0.953, P < 0.001). Kaplan–Meier survival curves showed that mortality risk was significantly different when patients were stratified based on RP% ( P < 0.001). This association was preserved in a multi-logistic regression analysis that included clinical confounders ( P < 0.014). This prospective study demonstrates that increased RP% identifies septic shock patients who have a high risk of death. RP% has the potential to act as a marker for patient stratification in future clinical trials.