Open AccessProspective, Randomized Comparison of Same-Day Dose of 2 Different Bowel Cleanser for Afternoon Colonoscopy
Author(s) -
TaeGeun Gweon,
Sang Woo Kim,
Yong-sun Noh,
Seawon Hwang,
Nayoung Kim,
Yoonbum Lee,
Soon-Wook Lee,
Sung Won Lee,
Jong Yul Lee,
Chul-Hyun Lim,
Hyung Hun Kim,
Jin Su Kim,
Yu Kyung Cho,
Jae Myung Park,
In Seok Lee,
MyungGyu Choi
Publication year - 2015
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000000628
Subject(s) - medicine , cleanser , colonoscopy , bisacodyl , tolerability , gastroenterology , cathartic , adverse effect , colorectal cancer , pathology , cancer
For afternoon colonoscopy, same-day administration of sodium picosulfate, magnesium oxide, and citric acid (PM/Ca) is recommended. However, few studies have evaluated the bowel-cleansing efficacy and safety of this regimen. The aim of this study was to compare the bowel-cleansing efficacy, side effects, and patient's tolerability of a same-day split administration of PM/Ca with polyethylene glycol (PEG) for afternoon colonoscopy. Patients were randomly assigned to a PM/Ca group or a PEG group. The PM/Ca group consumed 1 sachet of PM/Ca at 06:00 and 1 sachet of PM/Ca 4 hours before the colonoscopy. They also took 2 tablets of bisacodyl before sleep on the night before. The PEG group consumed 2 L of PEG at 06:00 and 2 L of PEG 4 hours before the colonoscopy. All subjects were instructed to finish the bowel cleanser or fluid at least 2 hours before colonoscopy. All colonoscopic examinations were performed in the afternoon on the same day. The bowel-cleansing efficacy was scored using 2 scales: the Ottawa Bowel Preparation Scale (OBPS) and the Aronchick scale. Ease of using the bowel cleanser was rated from 1 (very easy) to 5 (very difficult). Two hundred nine patients underwent colonoscopy. The bowel-cleansing scores by OBPS did not differ between groups (5.0 vs 4.9, P = 0.63). Ease of using the bowel cleanser was superior in the PM/Ca group ( P < 0.01). The cleansing efficacy of PM/Ca administered on the day of colonoscopy is comparable to that of PEG. Patients prefer PM/Ca.