Open AccessSenescence in pulmonary arterial hypertension: is there a link?
Author(s) -
Khrystyna Semen,
Aalt Bast
Publication year - 2022
Publication title -
current opinion in pulmonary medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.937
H-Index - 75
eISSN - 1531-6971
pISSN - 1070-5287
DOI - 10.1097/mcp.0000000000000879
Subject(s) - medicine , cardiology , pulmonary hypertension , intensive care medicine
Cellular senescence has been recognized as a promising target in the treatment of many cardiovascular diseases. The pathways involved in the development of senescence share many similarities with pathobiological mechanisms of pulmonary arterial hypertension (PAH). But the potential of senolytics to improve pulmonary hemodynamics and to reduce vascular remodelling in PAH has thus far not been investigated in depth.